Study of The Function and Molecular Mechanism of eIF3k in Apoptosis Regulation
碩士 === 國立臺灣大學 === 分子醫學研究所 === 93 === eIF3k, a 28 kDa protein, is the smallest subunit of eukaryotic translation initiation factor 3 complex and is evolutionally conserved among higher eukaryotes, including mammals, insects, worms and plants. However, genetic and biochemical studies failed to demonst...
| Main Authors: | , |
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| Format: | Others |
| Language: | en_US |
| Published: |
2005
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| Online Access: | http://ndltd.ncl.edu.tw/handle/26551761172090367733 |
| Summary: | 碩士 === 國立臺灣大學 === 分子醫學研究所 === 93 === eIF3k, a 28 kDa protein, is the smallest subunit of eukaryotic translation initiation factor 3 complex and is evolutionally conserved among higher eukaryotes, including mammals, insects, worms and plants. However, genetic and biochemical studies failed to demonstrate an essential role of eIF3k in general translation. Here, we identified a novel function of eIF3k in promoting apoptosis, as knockdown of endogenous eIF3k could de-sensitize cells to several apoptotic stimuli, such as UV irradiation
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