Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction
碩士 === 國立臺灣大學 === 流行病學研究所 === 93 === Many case-control association studies performed the “gene-dose analysis” to investigate the association between multiple loci and the disease. The authors found that the researchers in about one-third of these studies defined the high-risk genotypes (high-risk al...
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ndltd-TW-093NTU055440242015-10-13T11:12:49Z http://ndltd.ncl.edu.tw/handle/30157360097098302961 Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction 遺傳相關研究中的基因劑量分析:潛在的偏差及其校正方法 Hsiao-Yuan Huang 黃筱元 碩士 國立臺灣大學 流行病學研究所 93 Many case-control association studies performed the “gene-dose analysis” to investigate the association between multiple loci and the disease. The authors found that the researchers in about one-third of these studies defined the high-risk genotypes (high-risk alleles) as those that have higher genotype frequencies (allele frequencies) in the case group than in the control in the study. The authors performed Monte-Carlo simulation and found that even though there is no association between each locus and the disease, this kind of definition will show false-positive gene-dose relationships. The authors proposed a permutation correction method which is easy to perform and can correct the biases very effectively. The permutation correction method may become a standard procedure for a valid gene-dose analysis in the days to come. 李文宗 2005 學位論文 ; thesis 28 zh-TW |
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碩士 === 國立臺灣大學 === 流行病學研究所 === 93 === Many case-control association studies performed the “gene-dose analysis” to investigate the association between multiple loci and the disease. The authors found that the researchers in about one-third of these studies defined the high-risk genotypes (high-risk alleles) as those that have higher genotype frequencies (allele frequencies) in the case group than in the control in the study. The authors performed Monte-Carlo simulation and found that even though there is no association between each locus and the disease, this kind of definition will show false-positive gene-dose relationships. The authors proposed a permutation correction method which is easy to perform and can correct the biases very effectively. The permutation correction method may become a standard procedure for a valid gene-dose analysis in the days to come.
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李文宗 |
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李文宗 Hsiao-Yuan Huang 黃筱元 |
author |
Hsiao-Yuan Huang 黃筱元 |
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Hsiao-Yuan Huang 黃筱元 Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
author_sort |
Hsiao-Yuan Huang |
title |
Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
title_short |
Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
title_full |
Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
title_fullStr |
Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
title_full_unstemmed |
Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
title_sort |
gene-dose analysis in genetic association studies:a potential bias and its correction |
publishDate |
2005 |
url |
http://ndltd.ncl.edu.tw/handle/30157360097098302961 |
work_keys_str_mv |
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