Total synthesis of deoxyneocryptotanshinone II and analogues

• Main Authors: yi-ching Wu, 吳宜瑾
• Other Authors: 黎世源，董明兆
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/45616202133698881323

碩士 === 中國文化大學 === 應用化學研究所 === 93 === The dried roots of Salvia miltiorrhiza under the name Danshen has been used in Chinese traditional medicine for treatment of cardiovascular disease, hemorrhage, menstrual disorder, miscarriage, and swelling. According to literature reports, a lot of tanshinones were isolated and identified from S. miltiorrhiza and many of them have been also reported to exhibit diverse biological activities such as antitumor, antioxidant, and antiplatelet aggregation activities. Deoxyneocryptotanshinone II was isolated as a minor component from the roots of Salvia miltiorrhiza and the structure was elucidated by spectroscopic method. However, the synthesis and the biological activity were not reported yet. In this thesis we present here a convenient method to synthesize deoxyneocryptotanshinone II.