A study on risk factors of Polycystic Ovary Syndrome

• Main Authors: Ju-Yu Lin, 林茹玉
• Other Authors: Ching-Ying Yeh
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/41496120747734328850

碩士 === 臺北醫學大學 === 公共衛生學系 === 93 === In order to explore the risk factors, such as android obesity, insulin resistance, homocysteine, lipid profile of Polycystic Ovary Syndrome (PCOS) in women. A case-control study was performed. Two groups with and without PCOS women were included at the center for reproductive medicine and infertility in Taiwan Adventist Hospital. The demographic characteristics were collected by structural questionnaire that included the life habits, history of menstration, past history and family history etc. The blood samples were also collected for biochemical examination. Moreover, the concentration of blood trace element (selenium, chromium) in PCOS and non-PCOS women were also measured. Our results showed that insulin resistance (median of AC insulin: 9.0 vs. 4.22 μU/ml, p=0.0002; AC G/I ratio: 10.48 vs. 22.62, p=0.0003; HOMA: 2.09 VS. 0.98, p<0.0001; QUICKI: 0.34 vs. 0.39, p<0.0001), concentration of plasma homocysteine (median: 8.34 vs. 6.94 μmol/l, p=0.02) and dyslipidemia (median: triglyceride:82.0 vs. 62.5 mg/dl, p=0.004; cholesterol: 177.0 vs.155.0 mg/dl, p=0.0009) in the PCOS patients was significantly higher than in the non-PCOS patients. Waist circumference was high and concentrations of chromium, glutathione were low in PCOS women than non-PCOS women, but not significantly. Selenium and MDA were no finding. In multiple logistic regression analysis, Age, Total cholesterol/HDL ratio, pc sugar and HOMA (Homeostasis model assessment) had the best explanatory power for PCOS with coefficiency of determination 0.43. Because the risk factors of PCOS is identical to cardiovascular risk factors, therefore, low oil diet, exercise regularly, control the body weight that maybe the most important lifestyles for prevention. Several risk factor clusters together in PCOS women and its contribution to the development of cardiovascular disease need more evidence to confirm in the future.