Radiochemical Characteristics of Four New 99mTcO-Complexes with (NNO/S) ”3+1”Mixed Ligands

• Main Authors: Peng Wei Li, 彭薇莉
• Other Authors: Yao Hsueh Hua
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/2tg3uf

碩士 === 元培科學技術學院 === 影像醫學研究所 === 94 === Four novel ‘‘3+1’’ mixed ligand 99mTc(V)O complexes, 99mTcOL1L3, 99mTcOL1L4, 99mTcOL2L3, and 99mTcOL2L4, containing the NNO/S donor atom set have been prepared, where L1 = 1,3-diamino-2-hydroxypropane, L2 = 2,3-diaminopropionic acid monohydrochloride, L3 = ethyl 3-mercaptoacetate, and L4 = ethyl 3-mercaptopropionate. It was found that the 99mTc(V)O complexes are formed in a one-step procedure starting from pertechnetate at proper pH values in yields of 80-90% of radiochemical purity. The radiochemical characteristics of the four complexes were analyzed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), electrophoresis, and solvent extraction. As expected, the four complexes were lipophilic and neutral. In vitro stability studies showed the four complexes were practically stable for at least six hours at room temperature.