| Summary: | 碩士 === 崑山科技大學 === 機械工程研究所 === 94 === Biological cells obtain viscoelastic property from elaborate arrays of protein fibers known as cytoskeleton. With this viscoelastic property, a cell maintains its structural integrity and is able to move. Viscous property is obtained from cytoplasm, while the elasticity is obtained from cellular membrane. Cellular deformation and tank-tread motions are simulated with the rotating Kevin-Voigt model.
While traveling, red blood cells like to migrate to the central lumen of the vessel, this phenomenon is known as axial migration of red blood cells. Axial migration will lead to a red cell-free peripheral layer, where white blood cells travel at a much slower speed. This work will investigate the deformation of cells at different radial position within the vessel.
Tank-tread motion can be observed on white blood cells while they crawl on the wall the endothelial surface. A cell may undergo a tank-tread motion when the shear stress exceeds a certain threshold. Tank-tread motions are often observed on a drop of water flowing down an incline. Tank-tread motion is a mechanism to prevent the tumbling of the delicate interior of a cell.
To better understand the motions of red cells and white cells, a rotating Kelvin Voigt model is used to simulate the rotating motions.
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