Catalytic Asymmetric Reduction of Acetophenone by Ru and Chiral Camphor-derivatived β-amino alcohol

• Main Authors: Jing-Yan Jheng, 鄭敬嚴
• Other Authors: Kuang-Sen Sung
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/66714182051593135071

碩士 === 國立成功大學 === 化學系碩博士班 === 94 === Camphor is widely applied to catalytic asymmetric synthesis because of it’s two nature chiral center. We design and synthesis β-amino alcohol from camphor by a very highly stereoselecviv -e route and then we modify several different substituent group on the nitrogen. We achieve the goal by reductive amination because we want to get secondary amines. Instead of imines, we get the 5 member oxazolidine rings. Then open the rings, we obtain the desired Compound. Finally we apply the β-amino alcohols to the rutheniu catalytic asymmetric synthesis.