Summary: | 碩士 === 國立交通大學 === 統計學研究所 === 94 === Endophenotypes, which involve the same biological pathways as diseases but presumably are closer to the relevant gene action than diagnostic phenotypes, have emerged as an important concept in the genetic studies of complex diseases. In this report, we give some patterns about the developed index, the proportion of heritability explained (PHE) by the endophenotypes for validating endophenotypes. Besides, we provide a relevant confidence interval of PHE to perform a statistical test and to make some statistical inference. Using the relevant confidence interval of PHE, we construct some criteria to help us search a useful endophenotype.
|