Summary: | 碩士 === 國立中央大學 === 統計研究所 === 94 === Family-based and population-based are two types of designs for association studies.The family-based study in general is more robust than population-based study due to population stratification if the genetic markers and disease-susceptibility locus were linkage.Thus, family-based association study is a useful approach for detecting linkage and linkage disequilibrium between a disease gene and a marker in genetic analysis. Recently, the transmission/ disequilibrium test (TDT) and the allied tests have become popular tools in studies of association test. However, for the complex hereditary analysis, the type I error can't maintain a fixed significant level because of varing errors in genotyping. In this article, we try to construct and discuss statistics which are more robust under genotyping error.
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