Plasma adiponectin and breast cancer risk

• Main Authors: Chang Chia-Lin, 張嘉琳
• Other Authors: Sun Chien-An
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/01822712562310973517

碩士 === 國防醫學院 === 公共衛生學研究所 === 94 === Adiponectin is secreted from the adipose tissue, which modulating energy balance, increasing insulin sensitivity of various types of cells, and having a preventive role of anti-inflammation and anti-angiogenesis on cells. Based on the literature that obesity is an important risk factor of breast cancer and adiponectin is inversely related to obesity, we hypothesize that lower plasma adiponectin levels are associated with increased risk of breast cancer in women. A hospital-based case-control study involving 269 incident breast cancer cases and 269 cancer-free matched controls was conducted to evaluate this hypothesis. Questionnaire information and blood samples were taken from each subject. Plasma levels of adiponectin were measured by radioimmunoassay and the results were analyzed using logistic regression models. The study results showed that the odd ratios of breast cancer for women in the highest quartile, the second quartile and the third quartile of plasma adiponectin compared to women in the lowest quartile of adiponectin levels were 1.63(95% CI: 0.98~2.74), 1.40(95% CI: 0.82~2.39) and 1.13(95% CI: 0.66~1.93), respectively. Further prospective follow-up studies and mechanistic studies are needed to elaborate causal relationships between adiponectin and breast cancer risk.