Electrochemical Synthetic Application of Bisflavanones

• Main Authors: Tzu-Sheng-Chuang, 莊慈生
• Other Authors: Arh-Hwang-Chen
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/21215849611118128528

碩士 === 國立高雄師範大學 === 化學系 === 94 === Biflavonoids usually exist in natural plants. They were found to have some activities in hepatitis B virus, anti-cancer,anti-spasm, improving immunity. 6-Methoxyflavone were synthesized by Baker- Venkataraman Rearrangement. We tried to invesgate the factors which affect the electroorganic dimerization of 6-methoxyflavone was easily reduced by using electrochemical method to give two hydrodimers of 6,6’-dimethoxy-2,2’-biflavanone (racemate) and 6,6’-dimethoxy-2,2’- biflavanone (meso) and one reductive product of 6-methoxyfiavaanone. Their yields were dependent on the nature of electrodes, the kinds of supporting electrolytes and the reaction temperature. They were found to afford higher yields of 6,6’-dimethoxy-2,2’-biflavanone (racemate), 6,6’-dimethoxy-2,2’-biflavanone (meso) and 6-methoxyfiavaanone.(24.9﹪, 22.9﹪,and38.5﹪,respectively,) in the reaction condition of Pd(-)/C(+)-0.1MH2SO4/MeOH-20F/mol at 0℃