| Summary: | 碩士 === 國立台北護理學院 === 醫護管理研究所 === 93 === Graduate School: Department of Health Care Management, National
Taipei College of Nursing
Advisor: Chien-Jen Chen, Kung-Yee Liang, and Su-Chiu Chen
Author: Fang-Ju Sun
Title (Part 1): Efficacy of atropine treatment on progression of
myopia by GEE
Topics of myopia are important public health issues. For pupils who under -3.0 diopter, atropine (cycloplegics) is usually used to treat or prevent progression of myopia.
This thesis is to study efficacy of atropine treatment on progression of myopia. This research follows the trail throughout eighteen months, tracking 188 myopia pupils of 6 to 14 years old at Department of Ophthalmology in National Taiwan University Hospital to have measurements four times every six months by a three-group randomized design.
Data were for longitudinal repeated measuring or clustering, so the generalized estimating equation (GEE) was applied to analyze the particular risk and covariates for efficacy of atropine treatment on progression of myopia based on longitudinal repeated data on left and right eye.
The results for efficacy of atropine treatment on progression of myopia were pupils who used both multi-focal lenses and atropine every day, and who used multi-focal lenses, compared to regular lenses ones, diopter was controlled as time increasing. Pupils who used multi-focal lenses and atropine every day, compared to multi-focal lenses ones, diopter was also controlled better (statistically significant, p<0.0001).
The results can offer the reference for the relevant competent authority, making the prevention and health care policy for achieving purpose of preventive medicine to prevent and treat in early stages and to save the hospitalization cost even more finally.
Title (Part 2): Familial aggregation of NPC by GEE
The etiology of nasopharyngeal carcinoma (NPC) suggests the interaction of genetic and environmental factors. But past research had not analyzed odds ratio (OR) for relatives who had NPC within a family, considering correlated data. However, relatives who had NPC had higher OR, the main factor may be genetic.
The purpose is to study familial aggregation of NPC. NPC patients from six hospitals in Taiwan were recruited and linked to Taiwan Cancer Registry between 1994 and 1999. The criteria for inclusion as a proband were a subject with pathological diagnosed NPC. The data were obtained from personal interviews using structured questionnaires, consisting of smoking, eating salted fish and fermented food. A total of 928 NPC families were interviewed, consisting of 9799 relatives of parents, siblings, children and spouses.
Because research data are correlated data such as longitudinal repeated or clustered measurements, so the generalized estimating equation (GEE) was applied to analyze familial aggregation of NPC. Statistical models were considered smoking, eating salted fish and fermented food by adjusting for age and sex.
Research results for familial aggregation of NPC were OR about 3~4 (p<0.05) for siblings’ pairs within a family who had NPC and about 10 (p=0.0032) for parents-children pairs within a family who had NPC.
Relatives within a family who had NPC had higher OR, the relevant competent authority, can put more resources in the future, collect more patients’ families, set up the database of country, and educate and check the high risk NPC families to prevent from NPC.
|
|---|
