CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY

• Main Authors: Yu-San Huang, 黃鈺珊
• Other Authors: Cheng-Huang Lin
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/51806641029957746366

碩士 === 國立臺灣師範大學 === 化學系 === 94 === The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by GC/MS and then used as standards in a series of CE experiments. Using these R-(-)- and S-(+)-isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of -cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized. A comparison of the use of aqueous and non-aqueous solutions in association with -cyclodextrin for the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and non-aqueous solution conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of -cyclodextrin (aqueous, 25 ~ 60 mM; non-aqueous, 20 ~ 150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized.