CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY
碩士 === 國立臺灣師範大學 === 化學系 === 94 === The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by GC/MS and then used as standards in a series of CE experiments. Using these R-(-)- and S-(+)-isomers, the d...
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ndltd-TW-094NTNU50650172016-06-01T04:21:11Z http://ndltd.ncl.edu.tw/handle/51806641029957746366 CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY 以毛細管電泳螢光光譜法對尿液及藥錠中3,4-亞甲雙氧甲基安非他命(3,4-MDMA)及相關濫用藥物光學異構物之分析研究 Yu-San Huang 黃鈺珊 碩士 國立臺灣師範大學 化學系 94 The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by GC/MS and then used as standards in a series of CE experiments. Using these R-(-)- and S-(+)-isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of -cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized. A comparison of the use of aqueous and non-aqueous solutions in association with -cyclodextrin for the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and non-aqueous solution conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of -cyclodextrin (aqueous, 25 ~ 60 mM; non-aqueous, 20 ~ 150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized. Cheng-Huang Lin 林震煌 2006 學位論文 ; thesis 120 zh-TW |
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碩士 === 國立臺灣師範大學 === 化學系 === 94 === The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by GC/MS and then used as standards in a series of CE experiments. Using these R-(-)- and S-(+)-isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of -cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized.
A comparison of the use of aqueous and non-aqueous solutions in association with -cyclodextrin for the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and non-aqueous solution conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of -cyclodextrin (aqueous, 25 ~ 60 mM; non-aqueous, 20 ~ 150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation were optimized.
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author2 |
Cheng-Huang Lin |
author_facet |
Cheng-Huang Lin Yu-San Huang 黃鈺珊 |
author |
Yu-San Huang 黃鈺珊 |
spellingShingle |
Yu-San Huang 黃鈺珊 CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
author_sort |
Yu-San Huang |
title |
CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
title_short |
CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
title_full |
CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
title_fullStr |
CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
title_full_unstemmed |
CHIRAL SEPARATION OF 3,4-MDMA AND RELATED COMPOUNDS IN CLANDESTINE TABLETS AND URINE SAMPLES BY CAPILLARY ELECTROPHORESIS / FLUORESCENCE SPECTROSCOPY |
title_sort |
chiral separation of 3,4-mdma and related compounds in clandestine tablets and urine samples by capillary electrophoresis / fluorescence spectroscopy |
publishDate |
2006 |
url |
http://ndltd.ncl.edu.tw/handle/51806641029957746366 |
work_keys_str_mv |
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