| Summary: | 碩士 === 國立臺灣大學 === 醫學工程學研究所 === 94 === In recent years, the appearance of many epidemics have risen a disturbance and increased the casualties in the whole world. In epidemic diagnosis, the most important is to identify the pathogen which is a tiny organism to cause a disease. To prescribe medicine, it must be confirm with the pathogen. The methods of disease diagnosis classified into gene diagnosis and protein diagnosis at present The market of the in vitro diagnostic (IVD) technologies is approximately 30 billion U.S. dollars, and will see an annual average growth of 7% for the near future. There are still plenty room for IVD advancement.
In this research, we apply the polymer light-emitting diode and the surface micro-machining technology into the field of surface plasmon resonance (SPR), to construct a planar circular light source and a sensing gold film both 100um in width which produce SPR signal by aiming with the dimensional characterization in a resolution about 0.25 degree . Such that we can operate a fixed-angle SPR test with bio-molecule. The miniaturized SPR system has an opportunity for non-labeling outdoor sensing. The sensing chip is convenient in examination by saving not only the manpower of aiming optical pathway but the usage of lots optical equipments, prism, filter, and polarizer. Furthermore, it can lower the sample requirement and develop parallel diagnosis method by integrating the chip with the micro-fluidic channel system. This lab-on-a-chip system can be utilized in disease diagnosis and drug screen in the future.
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