| Summary: | 碩士 === 靜宜大學 === 食品營養研究所 === 94 === Hyperglycemia-induced platelet activation may play an important role on thrombogenesis in diabetic complications. Therefore, the purpose of this study was to investigate the effect of vitamin C and vitamin E supplements on platelets hyperactivity. Forty type 2 DM patients were randomly assigned into four experimental groups in this double-blinded study. Treatment groups were placebo, vitamin C (500 mg/d), vitamin E (400 mg α-TA/d) and vitamin C+E, respectively. After 8 weeks’ supplement, plasma concentration of vitamin C, vitamin E, MDA and total antioxidant status (TAS) were determined, and markers of activated platelet (PAC-1, CD62P) were analyzed by flow cytometry. The results of this study showed that plasma concentration of vitamin C and vitamin E was increased significantly by vitamin supplements. Plasma TAS tended to be ameliorated by vitamin supplements, however, plasma MDA concentration was decreased significantly in C and C+E groups, when compared to placebo group. The expression of PAC-1 was decreased by vitamin E supplement, and CD62P expression was impaired in vitamin C group. In conclusion, vitamin C and vitamin E supplements may be beneficial for type 2 DM patients in the prevention of thrombotic complications.
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