Serum vitamin B12、folate and blood relative markers in the elderly patients with mild cognitive impairment and Alzheimer’s dementia

• Main Authors: YANG HUI-MEI, 楊惠玫
• Other Authors: Shu-Jan Lan, Ph.D.
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/91629535223439688154

碩士 === 臺北醫學大學 === 保健營養學系 === 94 === Abstract This study was to compare serum vitamin B12、folate and blood-making related factors in the elderly with mild cognitive impairment (MCI) or various severity of Alzheimer’s disease (AD). MCI or AD was diagnosed by doctors. CDR (clinical dementia rating) was used to evaluate cognitive function. CDR scores of 0.5 were classified as MCI；1 as mild AD；2 as moderate AD and 3 as severe AD. All data required for the study were extracted from medical charts. A total of 218 subjects involved: 51 were MCI, 68 were mild AD, 50 were moderate AD and 49 were severe AD. MMSE scores in MCI, mild, moderate and severe AD groups were 27.1 ± 2.3、19.8 ± 4.7、16.4 ± 4.2 and 4.7 ± 2.7points, respectively. Serum vitamin B12 were 724.7 ± 410.7、656.1 ± 452.8、491.2 ± 215.1 and 326.6 ± 130.7 pg / mL. MCI or mild AD group had higher serum vitamin B12 than moderate and severe AD groups. Serum folate in four groups were 14.1 ± 5.1、14.8 ± 6.5、13.0 ± 4.8 and 9.7 ± 3.9 ng / mL. MCI or mild AD group had higher serum folate than severe AD group. Four groups had anemia according to Hb (Hct):MCI 43.1(33.3) %、mild AD 41.2(42.6) %、moderate AD 50.0(50.0) % and severe AD group 36.7 %(24.5 %). The prevalence of high MCV in four groups:7.8、20.6、14.0 and 8.2 %. Hypoalbuminemia occurred as 5.9、5.9、6.0 and 14.3 % in four groups. Poor liver function as indicated by high sGPT level was uncommon, only 2.0 ~ 2.9 % in four groups of subjects. In conclusion, serum vitamin B12 and folate decline as AD deteriorates. Anemia is common in the elderly with MIC or various degree of AD as indicated by blood related markers Hb、Hct or MCV and Hb is the most sensitive markers of anemia. Hypoalbuminemia occurs in 14.3 % of the elderly with severe AD, the highest prevalence among four groups. Keywords : Alzheimer’s disease, mild cognitive impairment, elderly, vitamin B12, folate