Improving Effects of Epigallocatechin-3-gallate on Hemorheological abnormality in Aging Guinea Pigs

• Main Authors: Chang, Yao-Yuan, 張耀元
• Other Authors: Liu, Der-Zen
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/83339581959998940887

碩士 === 臺北醫學大學 === 生物醫學材料研究所 === 94 === Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, has been shown to have pronounced anti-oxidative activity in animal models. In our study, we selected 24 months old aging guinea pigs as the experimental model, fed with diet containing 10, 20 and 30mg/kg/day of EGCG (experimental groups A, B, and C) for 28 days, respectively, in order to investigate the effects of EGCG on the abnormal hemorheological parameters of the aging guinea pigs. The results showed that blood biochemical parameters of the aging guinea pigs remained unaffected by orally given EGCG for 28 days compared to the controls groups D ( 0mg/kg/day of EGCG). The hemorheological results indicate that aging guinea pigs fed with low dose of EGCG (10mg/kg/day) did not have significant changes in hemorheological parameters compared with the control group. However, as the EGCG content reached to 20mg/kg/day, though there were still no prominent alteration in their erythrocyte aggregation, blood viscosity and blood viscoelasticity, but, the erythrocyte membrane MDA levels of aging guinea pigs started to exhibit significantly reduced (P<0.05) that seems to be responsible for the rise in erythrocyte deformability and the reduction in erythrocyte flow resistance. Moreover, the feeding of EGCG at 30mg/kg/day (high dose), significantly improved most of abnormal hemorheological parameters whether blood viscosity, blood viscoelaticity, erythrocyte aggregation or erythrocyte deformability.