Application of Principal Component Analysis for Gene Network
碩士 === 國立中正大學 === 化學工程所 === 95 === Cytokinesis, a process by which a dividing cell splits in two, plays a central part in cell division. Midbody is a transient “organelle-like” structure and consists of a compact, dense matrix of proteins, which are indispensable for cytokinesis. Inappropriate regul...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Online Access: | http://ndltd.ncl.edu.tw/handle/72629146251026615578 |
id |
ndltd-TW-095CCU05063024 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-095CCU050630242015-10-13T14:08:37Z http://ndltd.ncl.edu.tw/handle/72629146251026615578 Application of Principal Component Analysis for Gene Network 主成份分析在基因網路的應用 Pei-yin Liu 劉祐u 碩士 國立中正大學 化學工程所 95 Cytokinesis, a process by which a dividing cell splits in two, plays a central part in cell division. Midbody is a transient “organelle-like” structure and consists of a compact, dense matrix of proteins, which are indispensable for cytokinesis. Inappropriate regulation of midbody formation will significantly affect the terminal cytokinesis events and result in a multi-nucleate phenotype, which is a characteristic of tumorigenesis. In this study, we are aimed to apply principal component analysis to microarry data of midbody protein. Because the rareness of time-course human gene expression data, we adopt the publicly released yeast cell cycle microarray data, and look for the yeast ortholog of human midbody genes. By using principal components analysis we find that it can classification of the genes similar expression and similar function in cell cycle . We hope that the result can approve the biologist more understand the midbody. Feng-sheng Wang 王逢盛 學位論文 ; thesis 63 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
碩士 === 國立中正大學 === 化學工程所 === 95 === Cytokinesis, a process by which a dividing cell splits in two, plays a central part in cell division. Midbody is a transient “organelle-like” structure and consists of a compact, dense matrix of proteins, which are indispensable for cytokinesis. Inappropriate regulation of midbody formation will significantly affect the terminal cytokinesis events and result in a multi-nucleate phenotype, which is a characteristic of tumorigenesis. In this study, we are aimed to apply principal component analysis to microarry data of midbody protein. Because the rareness of time-course human gene expression data, we adopt the publicly released yeast cell cycle microarray data, and look for the yeast ortholog of human midbody genes. By using principal components analysis we find that it can classification of the genes similar expression and similar function in cell cycle . We hope that the result can approve the biologist more understand the midbody.
|
author2 |
Feng-sheng Wang |
author_facet |
Feng-sheng Wang Pei-yin Liu 劉祐u |
author |
Pei-yin Liu 劉祐u |
spellingShingle |
Pei-yin Liu 劉祐u Application of Principal Component Analysis for Gene Network |
author_sort |
Pei-yin Liu |
title |
Application of Principal Component Analysis for Gene Network |
title_short |
Application of Principal Component Analysis for Gene Network |
title_full |
Application of Principal Component Analysis for Gene Network |
title_fullStr |
Application of Principal Component Analysis for Gene Network |
title_full_unstemmed |
Application of Principal Component Analysis for Gene Network |
title_sort |
application of principal component analysis for gene network |
url |
http://ndltd.ncl.edu.tw/handle/72629146251026615578 |
work_keys_str_mv |
AT peiyinliu applicationofprincipalcomponentanalysisforgenenetwork AT liúyòuu applicationofprincipalcomponentanalysisforgenenetwork AT peiyinliu zhǔchéngfènfēnxīzàijīyīnwǎnglùdeyīngyòng AT liúyòuu zhǔchéngfènfēnxīzàijīyīnwǎnglùdeyīngyòng |
_version_ |
1717748613190254592 |