| Summary: | 碩士 === 高雄醫學大學 === 行為科學研究所碩士班 === 95 === Alzheimer’s disease is a neurodegenerative disease, manifested by global cognitive deterioration. The prevalence of Alzheimer’s disease is increased by aging and becomes a major health problem, especially in ageing society, such as Taiwan. Previous studies have shown that high serum total cholesterol is a risk factor for dementia, the clinical
hallmarks are including progressive memory loss. The objective of this study was to examine the relation of plasma lipid levels and lipid-related gene(APOE, CYP46) with memory performance in milddle-aged and older adults without dementia.
Our study used cross-section design and without control subjects. A total of 209 cognitively intact participants were recruited, the mean age(SD) was 67.87(6.80) years, the mean education was 11.07(3.91) years, 49.76％ were women. Memory and learning function were measured by logical memory (I)(II), world list (I)(II) and spatial span of the Wechsler Memory Scale-III (WMS-III). Serum total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, APOE and CYP46 gene polymorphisms were analyzed.
After adjustment for age, gender,education and socioeconomic status, participants with moderate total cholesterol levels (200-239mg/dL) performed better well than participants with desirable (＜200 mg/dL) and high total cholesterol levels (≧240 mg/dL) in learning ability(p=0.0092). We also found positive linear association of LDL with long-term memory on logical memory test. There was no significant difference between with and without APOEε4 genotype on Memory performance. We observed the significant associations between CYP46 gene polymorphisms and logical memory performance, SNP4 especially：subjects with AA genotype performed less well (p=0.0006).
In conclusion, CYP46 gene polymorphisms may play an important role in episodic memory performance, furthermore SNP4-AA genotype may be a risk factor of memory impairment. And moderate total cholesterol are associated with better learning performance. Finally, Cholesterol, APOE and CYP46 gene polymorphisms have no interaction on memory performance.
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