Design and Synthesis of Hybrid Agents Based upon Pyrrolo[2,1-c][1,4]benzodiazepine A-ring Linked with Enediyne

Design and Synthesis of Hybrid Agents Based upon Pyrrolo[2,1-c][1,4]benzodiazepine A-ring Linked with Enediyne

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所碩士班 === 95 === pyrrolo[2,1-c][1,4]benzodiazpines (PBDs) are a group of potent naturally occurring antitumor alkylating agents produced by Streptomyces species.Enediyne was either isolated or derived from Streptomyces, which are sourced from a specific generation mode of d...

Full description

Bibliographic Details
Main Authors:	Jium-Jia Liang, 梁峻嘉
Other Authors:	Jeh-Jeng Wang
Format:	Others
Language:	zh-TW
Published:	2007
Online Access:	http://ndltd.ncl.edu.tw/handle/23949274570513418050

Similar Items

Bioevaluation of Hybrid Based uponPyrrolo[2,1-c][1,4]benzodiazepine A-ring Linked with Triazole
by: Yong-Yong Lin, et al.
Published: (2012)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
by: Hsu, Mei Hui, et al.
Published: (1998)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
by: Hsu, Mei Hui, et al.
Published: (1998)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
by: lin fu lung, et al.
Published: (2001)

Design and Synthesis of Indole LinkedPyrrolo[2,1-c][1,4]benzodiazepineHybrides Anticancer Alkylating Agents
by: Chih-Sheng Cheng, et al.
Published: (2004)

Total Synthesis of Hybrid Agent Based upon Pyrrolo[2,1-c][1,4]benzodiazepine Moiety Linked at C8 and C2 Position
by: Ping-hsiu Shih, et al.
Published: (2007)

Design and Synthesis of Tail-to-tail Linked Pyrrolo[2,1-c][1,4]benzodiazepine Dimers and Hybride as Antitumor Agents
by: Wen-Yu Chung, et al.
Published: (2006)

Design and Synthesis of 8-Amino Pyrrolo[2,1-c][1,4 ]benzodiazepine Hybrid Agents
by: Ke, Dei-She, et al.
Published: (1997)

Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepineHybrid Agents via Click Chemistry
by: Wen-Ting Yu, et al.
Published: (2011)

Design and Synthesis of 8-Amino pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
by: Ping-Syh Tsai, et al.
Published: (2001)

Synthetic approaches to c-ring unsaturated DNA cross-linking pyrrolo[2,1-c][1,4]benzodiazepine dimers
by: Corcoran, Kathryn Elizabeth
Published: (1998)

Design and Synthesis of Tail-to-tail Linked Pyrrolo[2,1-c][1,4]benzodiazepine Dimers as Antitumor Agents
by: Meng-Hung Hsin, et al.
Published: (2004)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepines as Bifuntional Antitumor Agents
by: Lin, Wei-Ho, et al.
Published: (1996)

Design and Synthesis of Anticancer Alkylating Agents of Pyrrolo[2,1-c][1,4]benzodiazepine in C-ring-modified analogues
by: Lin. Miao-Chun, et al.
Published: (2003)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrids agent and Dimers as Antitumor Alkylation Agents
by: Chung-Yu Chen, et al.
Published: (2009)

Design, synthesis and biological evaluation of a DNA cross-linking antitumour agent based on the pyrrolo[2,1-c][1,4]benzodiazepine ring system
by: Wilson, Stuart Craig
Published: (1996)

Pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dithione
by: Sarah Ourahou, et al.
Published: (2010-07-01)

Molecular modelling studies on the pyrrolo[2,1-c][1,4]benzodiazepines
by: Adams, Lesley Jane
Published: (1998)

Design and Synthesis of Anticancer Alkylating Agents of Pyrrolo[2,1-c][1,4]benzodiazepine Containing Oxygen Group in C-ring
by: Yen-Chi Chen, et al.
Published: (2003)

Design and Synthesis of Anticancer Alkylating Agents of Pyrrolo[2,1-c][1,4]benzodiazepines Containing Amino Group in C Ring
by: Yu-Chen Lin, et al.
Published: (2002)

Design and Synthesis of Anticancer Alkylating Agents of Pyrrolo[2,1-c][1,4]benzodiazepines Hybrid Agents and Containing Sulfur Group in C-ring Analogues
by: Yu-Kai Shen, et al.
Published: (2005)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Conjugate Agents by Click Chemistry
by: Pei-Hua Lee, et al.
Published: (2009)

Synthesis and evaluation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids linked to a flavone moiety
by: Ahmed Kamal, et al.
Published: (2004-11-01)

Design and Synthesis of C2-Linked Pyrrolo[2,1-c][1,4 ]benzodiazepine DNA Interstrand Crosslinker as Antitumor Agents
by: Chuang, Hung-Wei, et al.
Published: (1997)

An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines
by: George Varvounis
Published: (2016-01-01)

Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Monomers and Dimers as Antitumor Alkylation agents
by: Ming-Kuan Hsu, et al.
Published: (2008)

The preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine building blocks and their application to the synthesis of A-to C-ring linked PDB oligomers
by: Fitzgerald, Leona
Published: (2003)

Design and Synthesis of A Ring C8 and C Ring C2 Oxygenated Pyrrolo[2,1-c][1,4]benzodiazepine as Anticancer Alkylating Agents
by: Li-Tzu Yen, et al.
Published: (2005)

SYNTHESIS OF PYRROLO[2,1-c] [1,4] BENZODIAZEPINE -11- HYDRAZINYL DEVRIVATIES AS A POTENTIAL ANTIMICROBIAL AGENT
by: Mingle, David, et al.
Published: (2018)

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines
by: Joel K. Annor-Gyamfi, et al.
Published: (2018-02-01)

Design and Synthesis of A Ring C8 Substituent and C Ring C2 Oxygenated Pyrrolo[2,1-c][1,4]benzodiazepine as Anticancer Alkylating Agents
by: Hua-Ping Chen, et al.
Published: (2004)

Design, synthesis and evaluation of DNA-binding oxazolo[2,3-c][1,4]benzodiazepines and pyrrolo[2,1-c][1,4]benzodiazepines
by: Jones, Garry B.
Published: (1991)

Synthetic, Structural and Biological Studies on C2-Substituted Pyrrolo [2,1-c] [1,4] Benzodiazepines
by: Antonow, Dyeison
Published: (2008)

Design, synthesis, and evaluation of pyrrolo[2,1-c] [1,4 benzodiazepines containing Endo/Exo unsaturation
by: Chen, Zhizhi
Published: (2005)

Design, synthesis and evaluation of linkers for the solid phase synthesis of pyrrolo [2,1-c][1,4] benzodiazepines
by: Spencer-Evans, Victoria Louise
Published: (2003)

Design, synthesis and evaluation of potential N10 protected pyrrolo[2,1-c][1,4] benzodiazepine prodrugs
by: Bird, Aisling Elizabeth
Published: (2004)

Synthesis, Characterization and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepines for Cytotoxicity and Serine β-lactamases Inhibition
by: Annor-Gyamfi, Joel K
Published: (2016)

Design, synthesis and evaluation of a scaffold and capping units based on the pyrrolo[2,1-c][1,4]benzodiazepines for combinatorial chemistry
by: Gonzaliez, Laura Maritza Calderon
Published: (2000)

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines
by: Kumaraswamy Sorra, et al.
Published: (2014-09-01)

Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives
by: Mingle, David
Published: (2019)