| Summary: | 碩士 === 中興大學 === 食品暨應用生物科技學系 === 95 === Metabolic syndromes (MS) are linked with central obesity and may cause cardiovascular diseases (CVD). Pro-inflammatory molecules are suggested to play an important role in developing metabolic syndromes; however the pathological role is still not quietly verified. We hypothesized the IL-6 and IL-10 may perform an important control role.
The aim of this study was to analyze the effects of an 8-week weight control program on serum inflammatory markers and risk factors for metabolic syndromes in 15 android obese subjects (average age, 41±11;BMI, 30.3±3.5) including 6 MS and 9 non-MS individuals. The results showed that before the weight control program was administrated, serum adiponectin concentration showed statistically negative correlations with BMI, weight, lean body mass, body fat, subcutaneous fat, and waist circumference. A significantly negative correlation existed between serums TNF-α and high density lipoprotein cholesterol (HDL-C) concentration, but a statistically positive correlation existed between serums TNF-α and blood pressures (Bps). Serum IL-6 concentration exhibited statistically positive correlations with the BMI, visceral fat, body fat, subcutaneous fat, and waist circumference. There was no significant correlation among these parameters and IL-10. TG concentration in MS subjects was significantly higher than those in non-MS subjects (P＝0.013). Serum IL-6 concentration in non-MS subjects was significantly higher than those in MS subjects (P＝0.053), however the other data were not significantly different between MS and non-MS subjects. 2) After the weight control program, the BMI, weight, lean body mass, TG, TC/HDL ratio, and TNF-α in MS subjects were significantly improved. In non-MS subjects, the BMI, weight, lean body mass, cholesterol, and waist circumference were also significantly improved. However, the improvement on indicators for metabolic syndromes in non-MS subjects was better than those in MS subjects. The concentration of IL-10 and TNF-α were significantly differential between MS and non-MS subjects (P＜0.05). 3) The net changes in fasting glucose, TG, TC/HDL, TNF-α increased in non-MS subjects through the weight control program, whereas the net changes of these markers decreased in MS subjects. The net adiponectin change increased in MS subjects, but decreased in non MS subjects.
In conclusion, the net changes of these indicators in MS and non-MS subjects were significantly different. As the weight control program was finished. The weight, BMI, and waist circumference in subjects with android obesity were indeed improved. The improvement on net variances of TG, TC/HDL, and TNF-α in MS subject was significant. Although the changes of adiponectin, IL-6, IL-10, and TNF-α were different between MS and non-MS subjects, the results from this study suggest that weight control may be beneficial to reduce CVD diseases via improving the indicators for metabolic syndromes.
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