Fabrication of SiO2/Fe3O4/Au Nanotubes for Potential Applications in Photothermal Therapy

• Main Authors: Ying-Ting Huang, 黃英婷
• Other Authors: Chen-Sheng Yeh
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/08529051251049365585

碩士 === 國立成功大學 === 化學系碩博士班 === 95 === In this study, SiO2 nanotubes were produced by using the water dissolvable sodium sulfate nanowires as hard template. SiO2 nanotubes could be synthesized by hydrolysis of tetraethoxysilan (TEOS) on the surface of Na2SO4 nanowires, followed by removal of Na2SO4 nanowires with H2O. The wall thickness of SiO2 nanotubes could be tuned by the change of the hydrolysis time of TEOS. Because of negative charge on the surface of SiO2 nanotubes, positively charged Fe3O4 nanoparticles could be deposited by electrostatic interaction. The -NH2 functional groups on the surface of SiO2/Fe3O4 nanotubes were functionalized with 3-aminopropyl-triethoxysilane（APTES）for the purpose of synthesis of SiO2/Fe3O4/Au nanotubes. Subsequently, Au seeds were fabricated by oxidation reduction method with protective agent sodium citrate. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) was added to conjugate the -NH2 of SiO2/Fe3O4 nanotubes and the –COOH groups existing onto Au seeds for the amide bonds formation. Finally, the Au growing stock solution was introduced to form Au nanoshell. It was focused that the near infrared (NIR) absorbance of the SiO2/Fe3O4/Au nanotubes depended on the compactness of the Au shell.