Studies on the Chemical Constituents from the Formosan Gorgonian Coral Rumphella antipathies

• Main Authors: Li-Fan Chuang, 莊立凡
• Other Authors: Ping-Jyun, Sung
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/3yqyes

碩士 === 國立東華大學 === 海洋生物科技研究所 === 95 === From the organic extract of a Formosan gorgonian coral Rumphella antipathies, collected off southern Taiwan coast, have resulted in the isolation of ten new caryophyllane-type derivatives, designated as rumphellatins A–D (1–4), rumphellolides A–F (5–10), along with two known compounds, kobusone (11) and isokobusone (12). In above metabolites, rumphellatins A–C (1–3) were the first caryophyllane-related natural products, which possess chloride atom and hemiketal groups in structures. In addition, rumphellolides A and B (5 and 6) were the first carboxylated caryophyllane-related natural products. The structures of 1–12 were elucidated by the interpretation of spectral data and by comparison the related spectral and physical data with those of literatures. In the biological activity testing, 1 and 8–10 exhibited activity in standard agar disk diffusion assay against Pseudomonas aeruginosa. Vibrio parahaemolyticus was inhibited by 6 and 8. Compounds 3, 10 and 12 exhibited activity against Staphylococcus aureus. Then, compounds 1 and 9 showed activity toward Escherichia coli.