| Summary: | 碩士 === 實踐大學 === 食品營養與保健生技研究所 === 95 === To study the effects of raspberry on the body weight and lipid metabolism, five-week old SD male rats were kept in chow diet for one week then divided into six groups: regular diet (R), regular diet with 5% raspberry (R5), regular diet with 10% raspberry (R10), high-fat diet (H), high-fat diet with 5% raspberry (H5), and high-fat diet with 10% raspberry (H10). The body weight and diet intake were measured once a week and every other day, respectively. After kept in the diets for six weeks, all animals were sacrificed to collect the blood, liver, and adipose tissues for further analysis. The results indicated that animals supplemented with raspberry started to show lower body weight compared with animals in non-supplemented groups after kept in the diets for four weeks. Raspberry did not have significant effects on the concentration of plasma high-density lipoprotein cholesterol, leptin, and weight of adipose tissues, but significantly lower the blood triglyceride level and liver weight of animals kept in regular diets. Supplementation of 10% raspberry had lowering effect on the blood total cholesterol of animals kept with regular diets, and low-density lipoprotein cholesterol of animals kept with either regular or high-fat diets. Supplementation of raspberry did not affect the expression of acyl-CoA:cholesterol acyltransferase, microsomal triglyceride transfer protein, HMG-CoA reductase, cholesterol ester transfer protein, and phospholipid transfer protein, but decreased the expression of lecithin: cholesterol acyltransferase in animals of H5 group. According to the results of this study, raspberry had blood lipid-lowering effect on the rats kept in regular diets.
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