| Summary: | 碩士 === 慈濟大學 === 醫學生物技術研究所 === 95 === Alzheimer disease (AD) is a neurodegenerative disease characterized by deposition and aggregation of amyloid-beta peptides (Aβ). Aβ is thought to play a central role in the neuronal death occurring in brains of AD patients. The aggregation of Aβ (1-40) has been shown to induce neurotoxicity, protein oxidation, lipid peroxidation, and reactive oxygen species generation in neurons. In the present study, we investigated the effect of the vitamin K derivates on Aβ (1-40)-induced neurotoxicity in cultured human SH-SY5Y neuroblastoma cells. When SH-SY5Y cells were treated with the vitamin K derivates together with Aβ (1-40), cells death decreased. Furthermore, when vitamin K derivates was added together with Aβ (1-40), the generation of free radicals and aggregative ability were also decreased in vitro. The effect of vitamin K derivates against Aβ (1-40) induced toxicity is at ng/ml level. This makes this compound to be a quite potent clinic therapy drug.
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