Identification of mRNAs regulated by RBMS3 during pancreas development

• Main Authors: Chung-Kuang Lu, 盧重光
• Other Authors: Ming-Ko Chiang
• Format: Others
• Language: en_US
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/89828782627192287748

碩士 === 國立中正大學 === 分子生物研究所 === 96 === The pancreas plays a crucial role in maintaining nutritional homeostasis, through the synthesis/secretion of enzymes and hormones. Considerable progress has been made in the understanding of the sequential activation of signal transduction pathways and the expression of transcription factors during pancreas development, including the transforming growth factor-β (TGF-β), Notch, Hedgehog pathways and PDX1, Ptf1a, Ngn3, Nkx family. Previously, a novel gene product (RBMS3) which contains two pairs of RNA binding motifs was found to be expressed strongly in early embryonic pancreas with the use of microarray assay and had been confirmed by in situ hybridization, immunofluorecsence and immunohistochemical staining. In addition, RBMS3 has also been shown to be expressed in hepatic stellate cells (HSCs). Its presence in HSCs stabilize the mRNA encoding the transcription factor Prx1 and thus increase collagen