| Summary: | 碩士 === 長庚大學 === 化工與材料工程研究所 === 96 === The purpose of study was to develop the synthesized and micelles-forming of (MPEG-b-PCL)-based block copolymers bearing functional side groups on the PCL block. MPEG-b-PBOCL diblock copolymers were synthesized by ring-opening polymerization of γ-Benzyloxy-ε-caprolactone（BOCL）using monomethoxy poly(ethylene glycol)（MPEG, Mn = 550 g mol-1）as the macroinitiator and SnOct2 as the catalyst. MPEG-b-PBOCL-b-PCL triblock copolymers were either synthesized by ring-opening polymerization of ε-caprolactone（ε-CL）using MPEG-b-PBOCL diblock copolymers and SnOct2 as the catalyst. The diblock or triblock copolymers were characterized by DSC, GPC, and 1H NMR. The Tg and Tm of block copolymers depend on the composition of block copolymers. For MPEG-b-PBOCL diblock copolymers exhibited only Tg that are amorphous. The length of PBOCL block was increased, the Tgs of MPEG-b-PBOCL were increased either. The length of PCL block was increased, the Tgs of MPEG-b-PBOCL-b-PCL were decreased and Tms of that were increased. The micelles of diblock or triblock copolymers in an aqueous phase were characterized by fluorescence, TEM, and DLS. The range of CMCs values were 0.76× 10-3 ~ 9.77×10-3 g L-1. The sizes of polymeric micelles were in the range of 87.0 ± 0.680 ~ 193.2 ± 6.406 nm. And the sizes of AM-loading micelles were in the range of 89.4 ± 0.497 ~ 134.8 ± 1.262 nm. However, the Zeta-potential of polymeric micelles were -2.3 ± 0.054 ~ -20.7 ± 0.994 mV. The shapes of micelles vary with the composition of block polymers were different length of spindle. The drug entrapment efficient and the drug-loading content of micelles depending on the composition of block polymers were described.
|
|---|
