High efficiency of screening α-glucosidase inhibitor from Chinese Herbal medicines using After Flowing Through Immobilized Receptor (AFTIR)

• Main Authors: Chung-Chia Chen, 陳重嘉
• Other Authors: Tung-Yuan Lai
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/83136741930399348246

碩士 === 中國醫藥大學 === 中國醫學研究所碩士班 === 96 === The number of diabetes patients is growing fast all over the world. Previous reports showed that lowering blood glucose levels may delay the occurrence of diabetes. Western medicines in clinical treatment of diabetes use oral hypoglycemic agents include α-glucosidase inhibitors which can effectively reduce postprandial blood glucose levels. In this study, AFTIR technology via the immobilization of α-glucosidase on chip was used to find several effective herbal extracts and has been verified as an effective method via finding the epicatechin gallate from green tea. Furthermore, the results show that Taxus blocks epigallocatechin gallate and α-glucosidase with blocking ratio of 35.9% and the activity of inhibiting α-glucosidase is significant. With the observations above, Taxus can therefore be a potential agent used for curing the diabetes patients in the future.