Synthesis of Poy(N-isopropyl acrylamide-methyl acrylic acid)/Nano ZnO Composite Latex and the application to Drug Control Release

• Main Authors: Tzu-Yu Pan, 潘姿羽
• Other Authors: Chia-Fen Lee
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/09203832795979306371

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 96 === In this study, the Poly(methyl methacrylate- methacrylate acid) /poly(N-Isoproplyacrylamide-methacrylate(poly(MMA-MAA)/poly(NIPAAm-MAA)) latex particles with the behaviors of pH sensitive and thermosensitive were synthesized by the method of soapless emulsion polymerization. Then the ZnO nano-particle bound on the latex particle to form the polymer/ZnO composite latex particles, which can be used as a drug carrier. Besides, the polymer/ZnO composite latex particles with hollow structure were investigated in this study. The hollow poly (NIPAAm - MAA) latex particles were synthesized by the way of three processes. The first stage was to synthesize the linear poly(methyl methacrylate-methyl acrylic acid) (poly(MMA-MAA)) seed latex particles. Then the NIPAAm, MMA and crosslinking agent (N,N’-methylenebisacrylamide) (MBA)) were polymerized in the presence of poly(MMA-MAA) seed latex particles to proceed the second stage reaction and formed the linear poly(MMA-MAA) / crosslinking poly(NIPAAm-MAA) core-shell latex particles. In the third stage process, the alkali solution was used to dissolve the linear core zone of core-shell latex particles to form the poly(NIPAAm-MAA) latex particles with hollow structure, and then the ZnO nano-particles bound on the surface of poly(NIPAAm-MAA) hollow latex particle to form the poly(NIPAAm-MAA)/ZnO hollow composite latex particle. The morphology of composite latex particle with dense structure or hollow structure was observed by transmission electron microscopy(TEM). Besides, we used caffeine as model drug to study the ability of control release of polymer/ZnO composite latex particle with dense structure and hollow structure respectively.