| Summary: | 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 96 === Pelvic inflammatory disease (PID) is caused by micro-organisms which colonize in the endocervix and ascend to the endometrium and fallopian tubes and become manifestations such as endometritis, pelvic peritonitis, tubal abscess, and salpingitis in the fallopian tube. We speculate that the regulation of cathepsin B and cystatin C is involved the inflammatory process and is related to the progression of PID. Thus, in this study, we sought to determine whether serum cathepsin B and cystatin C were efficient serum markers compared with WBC, neutrophils, and CRP in PID patients. In this study, ELISA analysis was employed to measure the serum levels of cathepsin B and cystatin C before and after routine protocol treatments in PID patients. A significantly increased expression of cathepsin B but decreased expression of cystatin C and significant correlations between neutrophils and cathepsin B, as well as between CRP and cathepsin B, were found in PID patients. Consistently, the ratio of cathepsin B to cystatin C correlated significantly with neutrophils and with CRP in PID patients. Increased expression of cathepsin B but a decreased level of cystatin C and an imbalance between cathepsin B and cystatin C may contribute to the progression of PID. Detection of cathepsin B and cystatin C can provide useful clinical information for PID.
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