Risk factors of multiple drug resistant Acinetobacter baumannii in MICU patients

• Main Authors: Min-Yueh, 楊敏岳
• Other Authors: 周明智
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/85148537386393195296

碩士 === 中山醫學大學 === 醫學研究所 === 96 === Background and Objective : The drug resistant rate of Acinetobacter baumannii (AB) have been constantly increased due to the abuse of antimicrobials in Taiwan. In 2006, the National Health Research Institute (NHRI) reported a surveillance in the fifth edition of Taiwan Surveillance of Antimicrobial Resistance (TSAR V) that Carbapenem resistant have progressively increased in nosocomial infection of AB bacilli. It reported that the resistant rate of A. baumannii in 2002 was 3%，in 2004 it increased to 16%，and until 2006 the rate is going up to 32%. Materials and Methods : A retrospective surveillance was held in our Intensive care unit to corroborate the above report. We collected patients’ sputum culture as our sample from January, 2006 to December, 2006. The result of Acinetobacter baumannii must show in double culture sampling. We used the logistic regression data mining regarding to patients’ age, sex, hospitalized duration before infection contaminate , antimicrobial used and duration, patients’ co morbidity, patients’ surgical history, patients’ CVP usage history. The multi-drug resistant is defined as those susceptible to antimicrobial agents showed intermediate or resistant. Result : The result showed the population group of multi-drug resistant of AB is 38 versus to 36 of non-MDRAB, respectively. The odds ratio of age is 1.03 , 95% CI is 0.995-1.011, p value=0.470 , Odds ratio of age plus chronic obstructive airway diseases (COPD) is 1.432, 95% CI 1.034-1.983, p=0.031 Conclusion : chronic obstructive pulmonary disease (C.O.P.D) is the only risk factor to multi-drug resistant of Acinetobacter baumannii (MDRAB) patients.