| Summary: | 碩士 === 中山醫學大學 === 口腔材料科學研究所 === 96 === The aim of this study was to synthesize bone cement with fast-setting and bioactivity for bone substitute applications. The sol-gel derived calcium/silicon powders were ground, followed by mixing with liquid phase. The study focuses on characterization of the bone cement before and after immersion in physiologically simulated solution, in addition to evaluation of properties of as-prepared powders. The results indicated that the particles size of ground was about 1μm. When mixing with the liquid phase, the setting time of the cement from powder was within 10 min. The diametral tensile strength value of the bone cement neither increase with increase in calcium content nor decrease with decrease in silicon content. The highest strength value is about 2.73 MPa. Regarding in vitro testing in simulated body fluid (SBF), the formation of apatite layer was apparent with increasing immersion time. And, the immersion time did not degrade the strength of the bone cement. The addition of naturally chitosan and gelatin to ceramic cements were also induce the precipitated apatite layer. Last not the least, the presently developed cements had a good bioactivity, which are expected as a potential bone repair material.
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