| Summary: | 碩士 === 高雄醫學大學 === 醫學研究所碩士班 === 96 === In Taiwan, the incidence of oral cancer increase every year. In recent decade, the number of chewing betel nut increase also. It was estimated that the number of chewing betel was about 2.0 to 2.8 million. Betel chewing is the main cause of submucosa fibrosis, leukoplakia and oral cancer. Not everyone chewing betel nut suffered from oral cancer. There was someone with long term betel nut chewing did not have oral cancer. There still remains controversy of betel nut chewing causing oral cancer and the difference may come from genetic origin. In the past time, there were only few papers concerning about the relationship between oral cancer and HLA class I A, B, C. and very few papers concerning about the relationship between oral cancer and HLA class II DQA1, DQB1. For further characterize the association between HLA DQA1, DQB1 and oral cancer in Taiwan, we investigated 134 Chinese oral cancer patients and 268 normal Chinese adults from Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital by using PCR-SSP (polymerase chain reaction-sequence specific primer). For 134 oral cancer patients, the male to female ratio is 34:1. 95.5% of all patients had history of betel nut chewing and all of the participants were Chinese living in Taiwan. We divided oral cancer patients into three mouth, tongue and cheek groups according to location. We found that there was no significant difference of HLA DQA1, DQB1 allele frequencies between oral cancer patients and normal adults for mouth, tongue and cheek, respectively and total oral cancer group. We observed a significantly decreased frequency of haplotype HLA DQA1*0103-DQB1*0601 and DQA1*0501-DQB1*0201 in our patients. From our data we suggests that HLA haplotype DQA1*0103-DQB1*0601 and DQA1*0501-DQB1*0201 may play some role in the pathogenesis of oral cancer.
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