Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所碩士在職專班 === 96 === A large number of natural and synthetic anticancer agents have been found to possess the 2-phenylnaphthalene skeleton. For example, 2-phenyl quinoline-8-carboxamide derivatives have been shown to possess DNA-binding capability and broad-spectrum activities in both leukemia and solid-tumor assays. Certain 4-anilino-2-phenylquinolone derivatives were also proved to possess potent anticancer activities by our research group. To explore more potent anticancer agents and establish structure-activity relationships, we described herein the preparation and antiproliferative activities of certain 4-anilino-2-styrylquinoline derivatives whose structures belong to the common structural pattern of 2-phenylnaphthalene with an additional conjugated double bond bridge. Their oxime and methyloxime derivatives were also synthesized for evaluation. Among them, compounds 11, 14a, 15a, and 15b exhibited significant antiproliferative activities.
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