Cyclization of 1-(2-alkynylphenyl)pyrroles to pyrrolo[1,2-a]quinolines
碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === 1-(2-alkynylphenyl)indoles 35 were prepared by the reaction of 2-alkynylbromobenzenes 33 with indole using CuI as a catalyst. Treatment of 35 with catalytic amount of Pd(OAc)2 or PdCl2 did not give any cyclization adduct. However, treatment of 35 with various...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/75182244748222195942 |
| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === 1-(2-alkynylphenyl)indoles 35 were prepared by the reaction of 2-alkynylbromobenzenes 33 with indole using CuI as a catalyst. Treatment of 35 with catalytic amount of Pd(OAc)2 or PdCl2 did not give any cyclization adduct. However, treatment of 35 with various of halogenating agents gave 3-haloindole derivatives in 15~81% yields.
On the other hand, reaction of 2-alkynylbiphenyls 42a and 42b with aryl iodides using Pd(OAc)2 as acatalyst gave the cyclization adducts 43a and 45a in 51% and 61% yields, respectively.
|
|---|