| Summary: | 碩士 === 國立成功大學 === 工程科學系專班 === 96 === In this thesis, a hand-held microcirculation microscope based on optical
design and image processing has been developed and is used to dynamically
grab capillary images. Currently, conventional microcirculation systems
based on standard microscopes have some defects such as inconvenient carry
and difficult clinical operation. Therefore, in this developed microcirculation
microscope, two new aspects are: 1) to utilize the high-brightness green LEDs
with a compact modular design to light capillarys due to heme absorption,
hence the contrast of the grabbed capillary images can be enhanced; 2) to
develop the hand-held microcirculation microscope based on low-aberration
lens design to achieve enlarged and clear imaging
To process the grabbed images based on digital image processing
technique, two main functions have been developed. One is to overcome the
transversal shaking between the operator’s hand and the patient’s measured
component based on a two-dimensional cross-correlation method and
reconstruct the capillary images with reduced shaking. The other is to develop
the physiological function to calculate the parameters of flow rate, vessel size,
blood distribution.
Finally, an autofocusing controller has been developed and is utilized to
overcome the longitudinal shaking. The clear images are locked by using a
hill-climbing method which seeks the Sobel peak value of the grabbing
images. The mechanism of the autofocusing controller can be referred to
overcome the restriction of longitudinal shaking in the further developing.
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