Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process
碩士 === 國立中央大學 === 化學工程與材料工程研究所 === 96 === Inorganic molecularly imprinted polymer (IMIP) based on tetramethoxysilane (TMOS) and methyltrimethoxysilane (MTMOS) by sol-gel process has been developed. The conditions of preparation, the ratio of water to monomers (R), pH value of competition solution, c...
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ndltd-TW-096NCU050630022016-05-11T04:16:04Z http://ndltd.ncl.edu.tw/handle/46277860714743083156 Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process 以溶膠-凝膠程序製備磺胺二甲嘧啶無機分子拓印高分子 Chun-li Peng 彭均莉 碩士 國立中央大學 化學工程與材料工程研究所 96 Inorganic molecularly imprinted polymer (IMIP) based on tetramethoxysilane (TMOS) and methyltrimethoxysilane (MTMOS) by sol-gel process has been developed. The conditions of preparation, the ratio of water to monomers (R), pH value of competition solution, calcination temperature, the ratio of TMOS to monomers (TMOS ratio), amount of hydrochloric acid and the reaction temperature were investigated. The competition experiment of the IMIP for template (sulfamethazine, SMZ) and analogue(sulfamethoxazole, SMO) were analyzed by High-Performance Liquid Chromatography (HPLC). The results showed that the higher selectivity of IMIP was obtained when pH value of competition solution was set to the pKa2 of SMZ. In addition, the adsorption of SMZ was increased with increase of the R value and the 2nd step calcination temperature. The crosslink and flexible of network were affected by TMOS ratio. Finally, amount of hydrochloric acid and the reaction temperature were also adjusted appropriately. The results showed that the best selectivity (α=21.8) of IMIP were obtained with R=10, the pH value of competition solution = 7.4, TMOS ratio = 1, amount of hydrochloric acid was 750 μl, the reaction temperature = 80℃ and the 2nd step calcination temperature =375°C. The IMIP (AdSMZ=2.18 μmol/g, α=21.8) was obtained the more efficiency than non-imprinted polymer (AdSMZ=1.62 μmol/g, α=6.23). Hui Chen 陳暉 2008 學位論文 ; thesis 70 zh-TW |
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碩士 === 國立中央大學 === 化學工程與材料工程研究所 === 96 === Inorganic molecularly imprinted polymer (IMIP) based on tetramethoxysilane (TMOS) and methyltrimethoxysilane (MTMOS) by sol-gel process has been developed. The conditions of preparation, the ratio of water to monomers (R), pH value of competition solution, calcination temperature, the ratio of TMOS to monomers (TMOS ratio), amount of hydrochloric acid and the reaction temperature were investigated. The competition experiment of the IMIP for template (sulfamethazine, SMZ) and analogue(sulfamethoxazole, SMO) were analyzed by High-Performance Liquid Chromatography (HPLC).
The results showed that the higher selectivity of IMIP was obtained when pH value of competition solution was set to the pKa2 of SMZ. In addition, the adsorption of SMZ was increased with increase of the R value and the 2nd step calcination temperature. The crosslink and flexible of network were affected by TMOS ratio. Finally, amount of hydrochloric acid and the reaction temperature were also adjusted appropriately. The results showed that the best selectivity (α=21.8) of IMIP were obtained with R=10, the pH value of competition solution = 7.4, TMOS ratio = 1, amount of hydrochloric acid was 750 μl, the reaction temperature = 80℃ and the 2nd step calcination temperature =375°C. The IMIP (AdSMZ=2.18 μmol/g, α=21.8) was obtained the more efficiency than non-imprinted polymer (AdSMZ=1.62 μmol/g, α=6.23).
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author2 |
Hui Chen |
author_facet |
Hui Chen Chun-li Peng 彭均莉 |
author |
Chun-li Peng 彭均莉 |
spellingShingle |
Chun-li Peng 彭均莉 Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
author_sort |
Chun-li Peng |
title |
Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
title_short |
Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
title_full |
Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
title_fullStr |
Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
title_full_unstemmed |
Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process |
title_sort |
preparation of inorganic molecularly imprinted polymers based on sulfamethazine by sol–gel process |
publishDate |
2008 |
url |
http://ndltd.ncl.edu.tw/handle/46277860714743083156 |
work_keys_str_mv |
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