Some procedures for solving the Magnetoencephalography inverse problem

• Main Authors: Hung-I Pai, 白宏益
• Other Authors: H.C. Paul Lee
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/31322445924429317335

博士 === 國立中央大學 === 物理研究所 === 96 === Magnetoencephalography (MEG) provides dynamic spatial-temporal insight of neural activities in the cortex. Because the number of possible sources is far greater than the number of MEG detectors, the proposition to localize sources directly from MEG data is notoriously ill-posed. Here we develop an approach based on data processing procedures including clustering, forward and backward filtering, and the method of maximum entropy. We show that taking as a starting point the assumption that the sources lie in the general area of the auditory cortex (an area of about 40 mm by 15 mm), our approach is capable of achieving reasonable success in pinpointing active sources concentrated in an area of a few mm''s across, while limiting the spatial distribution and number of false positives.