Prediction of eukaryotic protein subcellular localization

• Main Authors: Shu-Pin Chen, 陳書品
• Other Authors: Jorng-Tzong Horng
• Format: Others
• Language: en_US
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/10932435428409959975

碩士 === 國立中央大學 === 資訊工程研究所 === 96 === Prediction of subcellular localization of various proteins is an important and well-studied problem. Each compartment in cell has specific tasks, and proteins in each compartment are synthesized to fulfill these tasks. Proteins localized in the same compartment are thought to have the same or similar function. Knowledge of the subcellular localization of a protein can significantly improve target identification during the drug discovery process. Current available methods extract information from amino acid sequence or signal peptide and lack more biological features like post-translational modification. We develop an integrated system for biologists to know which localization the proteins from eukaryote is located to. The system is based on protein sequence composition, signal peptide, protein domains from Pfam and homologs search.