| Summary: | 碩士 === 國立中央大學 === 機械工程研究所 === 96 === The scaffold for tissue engineering provides cell adhesion and growing environment. Combining regulatory factor and bio-reactor can induce cell differentiation and tissue regeneration. The three dimensional structure of the scaffold affects cell migration and the flow of medium. Therefore the structure design and fabrication method of scaffolds have great influence for cell culture inside the scaffold. The structure of the scaffold can be designed by applying computer-aided design or generated from CT image model.
This research is to develop a software program to fabricate scaffold models, including the planning of scaffold and supporter path and the control interface of the processing machine, and to solve suspending problems of path points of scaffolds so that the quality of scaffolds can be improved. In the path planning of scaffolds, the path points are derived by finding the intersection points of the slice contour and paths and then judged if they are suspended in the air. If any path point is suspended, it will be replaced by the path point on the next lower layer, which is closest to the projection of the path point on the next lower layer, so that material will not accumulate. Also, the path pints will be connected sequentially to form several continuous paths to save fabrication time. On the other hand, the supporter area of each layer is derived by finding the difference between its scaffold area and the union of the scaffold areas of all layers above this layer. The path points of the supporter area are determined by analyzing and categorizing those of the scaffold areas above this layer. Finally, the supporter paths will be judged whether they are collided with the scaffold paths. If a collision happens, the position of the supporter path point will be modified. The path planning simulation experiment using an ear model shows that the proposed method is definitely able to improve the production quality of scaffolds.
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