| Summary: | 碩士 === 國防醫學院 === 護理研究所 === 96 === The purpose of this study was to examine the relationship between neuropsychiatric symptoms and quality of life in patients with Parkinson`s disease. Method: Ninety patients diagnosed by two neurologists at a teaching hospital in north Taiwan were recruited. The clinic examinations and interview were carried out. Study instruments including Beck Depression Inventory (BDI-II),The Parkinson’s Disease Questionnaire-39 Item (PDQ-39),Mini Mental State Examination(MMSE) ,and Unified Parkinson`s Disease Rating Scale(UPDRS）were used to evaluate patients . The data were analyzed by using frequency, percentage, average, standard deviation, independent-sample t test, Pearson’s product moment correlation, and mutiple regression. The SPSS for Window 13.0 was used. Result: The average BDI was 13.32 (SD =8.43). Sex（t=-3.97,p＜.01,education level(F=2.63, p＜.05),using antidepression medication（t=-2.68,p＜.01）,duration(r=.21, p<.05),MMSE(r=-.30,p<.01), Hoehen and Yahr stage(r=.38,p<.05),UPDRS total score(r=.42,p<.01) were significantly associated with depression. PDQ-39, sex, and education level explain 51.5% of the variance of depression（F=30.43, p＜.001）.The mean of PDQ-39 was 26.26 (SD = 16.67). Age(r=.30, p<.05),MMSE(r=-.57, p<.01), Hoehen and Yahr stage(r=.79, p<.01),BDI score (r=.62, p<.01), and UPDRS total score(r=.90, p<.01) were related to PDQ-39. UPDRS total score, and depression explained 78.3% of the variance of quality of life. Depression is one of quality of life predictors.Conclusion: Parkinson`s disease influence not only patients’physiological status, but also psychological mood. The lower the depression the better the quality of life in patients with Parkinson`s disease.
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