Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan
碩士 === 國立中山大學 === 生物科學系研究所 === 96 === Taxol is a complex polyoxygenated diterpene isolated from Pacific yew (Taxus brevifolia). The structures of Taxoids are diversified with species, season and growth environment and the clinical effectiveness of Taxol as a microtubule-stabilizing therapeutic agent...
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ndltd-TW-096NSYS51120062019-05-15T19:18:43Z http://ndltd.ncl.edu.tw/handle/d8zhr4 Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan 台灣產南洋紅豆杉雙萜類成分研究 Chuan-fu Jhuang 莊傳富 碩士 國立中山大學 生物科學系研究所 96 Taxol is a complex polyoxygenated diterpene isolated from Pacific yew (Taxus brevifolia). The structures of Taxoids are diversified with species, season and growth environment and the clinical effectiveness of Taxol as a microtubule-stabilizing therapeutic agent for treatment of several malignancies has motivated many scientists to isolate new taxoids and investigate their anti-tumor activities. In this continuing search for new and bioactive natural taxoids, reinvestigation of the acetone extract of the twigs, needles and branches of Taxus sumatrana (Taxaceae) afforded thirty-seven taxane diterpenes esters, including sumataxins sumataxin A (1)、sumataxin B (2)、sumataxin C (3)、sumataxin D (4)、taxuyunnanine C (5)、5a,7B,9a,10B,13a-petaacetoxy-4(20),11-taxadiene (6)、2a,5a,9a,10B,14B-pentaacetoxytaxa-4(20),11-taxadiene (7)、14B-hydroxytaxusin (8)、2a-deacetoxytaxinine J (9)、taxa-4-(20),11-diene-2a,5a,7B,9a,10B,13a-hexaol hexaacetate (10)、1-dehydroxy baccatin VI (11)、7B,9a,10B,13a,20-pentaacetoxy-2a-benzoyloxy-4a,5a-dihydroxytax-11-ene (12)、taxacin (13)、baccatin VI (14)、taxuspinanane J (15)、2-deacetoxy-5-decinnamoyltaxinine J (16)、N-Methyl taxol C (17)、10-deacetyl yunnanaxane (18)、taxumairol B (19)、taxinine M (20)、baccatin III (21)、taxuspinanane I (22)、taxumairol K (23)、wallifoliol (24)、13-oxo-baccatin III (25)、taxol (26)、7-epi-10-deacetyl taxol (27)、10-deacetyl-13-oxo-baccatin III (28)、19-hydroxybaccatin III (29)、10-deacetyl taxol (30)、10-deacetyl-baccatin III (31)、13-acetyl-13-decinamoyltaxachinin B (32)、5-deacetyltaxachitriene B (33)、5-epicanadensene (34)、taxezopidine F (35)、13a,7B-diacetoxy-2a,5a,10B-trihydroxy-9-keto-2(3→20)abeotaxane (36)、2-deacetyl taxine B (37). The structures of new compounds were established on the basis of their spectroscopic analyses. Among them, compounds 1, 2, 3 and 4 are new compounds from natural source, 2a-deacetoxytaxinine J (9)、taxuspinanane J (15) had effects on PBMC (Peripheral Blood Mononuclear Cells) proliferation, and sumataxin A、D (1、4) had light exhibitedactivity of HSV-1. Chang-hung Chou Ya-ching Shen 周昌弘 沈雅敬 2008 學位論文 ; thesis 133 zh-TW |
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碩士 === 國立中山大學 === 生物科學系研究所 === 96 === Taxol is a complex polyoxygenated diterpene isolated from Pacific yew (Taxus brevifolia). The structures of Taxoids are diversified with species, season and growth environment and the clinical effectiveness of Taxol as a microtubule-stabilizing therapeutic agent for treatment of several malignancies has motivated many scientists to isolate new taxoids and investigate their anti-tumor activities.
In this continuing search for new and bioactive natural taxoids, reinvestigation of the acetone extract of the twigs, needles and branches of Taxus sumatrana (Taxaceae) afforded thirty-seven taxane diterpenes esters, including sumataxins sumataxin A (1)、sumataxin B (2)、sumataxin C (3)、sumataxin D (4)、taxuyunnanine C (5)、5a,7B,9a,10B,13a-petaacetoxy-4(20),11-taxadiene (6)、2a,5a,9a,10B,14B-pentaacetoxytaxa-4(20),11-taxadiene (7)、14B-hydroxytaxusin (8)、2a-deacetoxytaxinine J (9)、taxa-4-(20),11-diene-2a,5a,7B,9a,10B,13a-hexaol hexaacetate (10)、1-dehydroxy baccatin VI (11)、7B,9a,10B,13a,20-pentaacetoxy-2a-benzoyloxy-4a,5a-dihydroxytax-11-ene (12)、taxacin (13)、baccatin VI (14)、taxuspinanane J (15)、2-deacetoxy-5-decinnamoyltaxinine J (16)、N-Methyl taxol C (17)、10-deacetyl yunnanaxane (18)、taxumairol B (19)、taxinine M (20)、baccatin III (21)、taxuspinanane I (22)、taxumairol K (23)、wallifoliol (24)、13-oxo-baccatin III (25)、taxol (26)、7-epi-10-deacetyl taxol (27)、10-deacetyl-13-oxo-baccatin III (28)、19-hydroxybaccatin III (29)、10-deacetyl taxol (30)、10-deacetyl-baccatin III (31)、13-acetyl-13-decinamoyltaxachinin B (32)、5-deacetyltaxachitriene B (33)、5-epicanadensene (34)、taxezopidine F (35)、13a,7B-diacetoxy-2a,5a,10B-trihydroxy-9-keto-2(3→20)abeotaxane (36)、2-deacetyl taxine B (37). The structures of new compounds were established on the basis of their spectroscopic analyses. Among them, compounds 1, 2, 3 and 4 are new compounds from natural source, 2a-deacetoxytaxinine J (9)、taxuspinanane J (15) had effects on PBMC (Peripheral Blood Mononuclear Cells) proliferation, and sumataxin A、D (1、4) had light exhibitedactivity of HSV-1.
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author2 |
Chang-hung Chou |
author_facet |
Chang-hung Chou Chuan-fu Jhuang 莊傳富 |
author |
Chuan-fu Jhuang 莊傳富 |
spellingShingle |
Chuan-fu Jhuang 莊傳富 Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
author_sort |
Chuan-fu Jhuang |
title |
Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
title_short |
Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
title_full |
Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
title_fullStr |
Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
title_full_unstemmed |
Studies on Diterpenoid Constituents from Taxus sumatrana in Taiwan |
title_sort |
studies on diterpenoid constituents from taxus sumatrana in taiwan |
publishDate |
2008 |
url |
http://ndltd.ncl.edu.tw/handle/d8zhr4 |
work_keys_str_mv |
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