Novel Cadmium tetrazole compounds development of hydrothermal synthesis for biological toxicity test & MCFs as a drug carrier for BSA release

• Main Authors: Tsung-Yuan Chang, 張宗元
• Other Authors: Hsiu-Mei Lin
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/03019196466553243041

碩士 === 國立臺灣海洋大學 === 生物科技研究所 === 96 === The purpose of this thesis uses the [2+3] cycloaddition reactions of cyano with NaN3 through “ the in situ ligand hydrothermal syntheses system” afford the [Cd3(mtta)3(N3)3]•2H2O ; mtta=5-Methyl-1H-tetrazole. This compound is a 3D networks crystal which contains the tetrazole functional group. By the X-ray diffraction analysis, the colorless crystal crystallizes in the tetragonal system, space group I 2m, with a=22.1918(4)A，b=22.1918(4)A，c=18.5523(7)A，α=β=γ=90°. We could find that the five-member ring of mtta and six-fold coordination of Cadmium atom can form a fullerene-like structure. Then it can be observed a hollow sphere micelle, which connecting to each other to structure of a string of bean with ordered and identical pore size in the network. Otherwise, in the aspect of the optical characterization, it could be observed blue and green fluorescent emission which is emitted at 226nm and 325nm laser, respectively. The tetrazole functional group has found a wide range of application in many area. In medicinal chemistry, it act as a bioisoteres for a carboxylic acid group in their nonclassical isosteres relation, comparing the biological toxicity test and similar compound with [Cd3(mtta)3(N3)3]•2H2O. Research on mesoporous materials for biomedical purposes has experienced an outstanding increase during recent years. Mesoporous silica have stable uniform mesoporous structure, high surface area, tunable pore sizes with narrow distributions, well-defined surface properties, nontoxic nature, and good biocompatibility. For drug-delivery system, the mesoporous materials as a carrier unlike traditional therapies, which show a saw-tooth curve of drug concentration in plasma, it can maintain therapeutic levels during the treatment period. Unlike MCM-41 and SBA-15, which have two-dimensional mesopore structures, mesocellular silica foams (MCFs) is a new class of three-dimensional(3D) hydrothermally robust materials with ultra-large mesopores. In terms of the textural and framework structure, the MCFs materials resemble aerogels and are composed of uniform spherical cells interconnect by windows with a narrow sizes substantially larger than those of any other mesostructures. According to the advantages of structure about MCFs, it is potential to be macro-molecule carrier.