Enhanced sensitivity of surface plasmon resonance biosensor by using silver nanoparticles

• Main Authors: Tzu-Cheih Peng, 彭眥杰
• Other Authors: Hai-Pang Chiang
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/11959599664037198586

碩士 === 國立臺灣海洋大學 === 光電科學研究所 === 96 === The goal of this thesis is to study the enhancement of the sensitivity of surface-plasmon-resonance （SPR） biosensor by silver nanoparticles. We fabricate silver nanoparticles on silver films by using thermal evaporation. The SPR phase detection system is constructed to measure the sensitivity of SPR sensor. First, we measure the sensitivity of phase signal of SPR sensor from silver films at different refractive index of glucose solution. The results are compared with the ones taken from silver-particle/silver-film with different evaporation parameters. We find the sensitivity of SPR sensor with silver-particle/silver-film is more sensitive than that of silver films under the specific condition of evaporation. Moreover, we find that there is a trend between the temperature and the thickness of silver particles and the sensitivity of SPR sensor. If we keep the substrate non-rotational, the thickness of particle is 5nm and the temperature is 100℃ in the evaporation process, the sensitivity of SPR sensor could be up to 10-8. In conclusion, we find that the structure of silver silver-particle/silver-film is more sensitive than that of gold film/gold particle or a single layer of metal film in SPR sensor.