Optimizing Laser Therapy Design for Heat Shock Protein and Injury Expression

• Main Authors: Yuan-Sung Chang, 張淵菘
• Other Authors: 陳誠亮
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/97955876034289482548

碩士 === 國立臺灣大學 === 化學工程學研究所 === 96 === Hyperthermia therapy is a type of cancer treatment on the use of laser to generate high temperature to damage and kill the tumor cells. Nevertheless, the curative effect of such therapy is influenced by the formation of heat shock proteins (HSP). HSP are a group of protective proteins produced by cells while the body is exposed to elevated temperatures, which have the functions to restore the denatured proteins and enhance the heat resistance of cells. Generally speaking, both healthy cells and tumor cells will synthesis HSP under heat, and therefore it is contributive to the clinical application of hyperthermia therapy to investigate and analyze the expression of HSP in body tissues by an adequate model. This work presents the simulations for three different examples by means of single laser and multi-laser, respectively. Through the procedure of optimization, the optimal treatments for corresponding examples are found, which not only restrain the expression of HSP in tumor cells to cause them the anticipant thermal damage, but also encourage the expression of HSP in healthy cells to mitigate their injury. The first two examples are about the external and internal laser treatments for a regular-shaped tumor, whereas the third example involves the external laser treatment for an irregular -shaped tumor. Results of those three examples have all shown that the tumor cells are effectively damaged while the thermal damage to healthy cells is varied with different operating modes of laser treatment. In the main, the curative effect of multi-laser is better than that of single laser, especially for the irregular-shaped tumors. It is because the use of multi-laser is easier to govern the temperature distribution as well as the damage degree and the expression of HSP in body cells.