The Effect of Resveratrol on γδ T cells

• Main Authors: Kuang-luen Wu, 吳光倫
• Other Authors: Chum-ming Lin
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/c4jj48

碩士 === 東吳大學 === 微生物學系 === 96 === Innate immunity response for resistance for the foreign substance first defense line, but the innate immunity responded that does not need to present cell's stimulation after the antigen to be possible to induce the immune response. In peripheral blood, there are exhibit γδ T cell receptor, called for γδ T cell, γδ T cell is one kind of innate immunity , has exhibited in the peripheral blood monocyte cell about 1-10%, γδ TCR also exists in the lymphoid organ (e.g. spleen and lymph node and so on) as well as the skin, the tongue, the esophagus, the trachea, the lung and the intestines and so on the epidermis. γδ T cell will secrete each kind of cytokine and have cytotoxicity ability. γδ T cell also has the anticancer treatment and the immunity regulation function. Resveratrol is the polyphenol compound which separates from the grape skin, Resveratrol has the anti-inflammation, suppress many kinds of tumour cells and prevention cardiovascular disease's ability. This study wants to know that Resveratrol anticancer ability to the influence of γδ T cell. The result exhibited that Resveratrol will not affect γδ T cell receptor,and high concentration (500 nM) will cause γδ T cell proliferation to be many. But has stimulated by way of resveratrol γδ the T cell has the varying degree in the different number of days kills by cytotoxicity regarding jurkat.