| Summary: | 碩士 === 臺北醫學大學 === 護理學研究所 === 96 === Title of Thesis: Arterial stiffness and Ambulatory Blood Pressure in Normotensives with the Metabolic Syndrome
Institution: Graduate Institute of Nursing, Taipei medical University
Author: Lin-Fang Chen
Thesis directed by: Pei-Shan Tsai, Ph. D., Associate Professor
Background: Metabolic syndrome (MS) is associated with an increased risk for cardiovascular events. Influence of the MS on arterial stiffness has been supported by previous studies. Artery stiffness is an important predictor of cardiovascular morbidity and mortality. This association could contribute to the higher cardiovascular risk in MS. Disruptions of circadian rhythm of blood pressure (BP) assessed by ambulatory BP monitoring, such as excessive morning surge and excessive nocturnal dipping or blunted nocturnal dipping (non-dipping), have been shown to be associated with target organ damage. While some studies have shown that MS may predict non-dipping status, others have shown contradicting results. Whether or not individuals with MS exhibit a non-dipping status may depend on the degree of arterial stiffness. Moreover, MS and non-dipping may share the some pathogenesis. This study, therefore, aims to investigate the relationship between arterial stiffness and parameters of ABP in normotensive individuals with MS.
Methods: Arterial stiffness was determined by cardio-ankle vascular index (CAVI) and internal common carotid intima using ultrasound. Ambulatory blood pressure was measured with an BP monitor every 30 minutes for two 24-hour period.
Results: A total of 88 participants enrolled in the study and data from 77 participants were included for data analysis. There was no significant correction between CAVI and internal common carotid intima (r =- 0.29, p = .17). MS score significantly corrected to CAVI(r = .3, p = .009). CAVI significantly correlated to dipping status (r = .3, p = .009). The three groups with different dipping status significantly differed in the CAVI value and the morning BP surge ( F=4.72, p = .011; F=6.73, p = .002 ). The extreme dippers had significantly higher levels of CAVI and morning BP surge compared to the non-dippers ( p = .012, p = .002)。
Keyword: Metabolic Syndrome, Ambulatory Blood Pressure, Cardio-ankle Vascular Index.
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