Hemorheological study of hyperthyroidism inducedtriiodothyronine in rats.

• Main Authors: Chih-Yu Chien, 錢芝宇
• Other Authors: Der-Zen Liu
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/34789639239093776847

碩士 === 臺北醫學大學 === 生物醫學材料研究所 === 96 === A large amount of thyroine cost Hyperthyroidism, and it will affect the health of the human body; this includes oxidative damage and the increases of fibrinogen in blood. When oxidative damage affects red blood cell, except the function of carrying oxygen will decrease, also causes decrease in deformability. This affection will enables difficulty when blood cells pass through the capillary, and slowing down its flow rate in tissues. However, fibrinogen gathers the red blood cells decreases the blood flow rate, and increases the viscosity in blood. The goal of this research is to confer using triiodothyronine leads the unusual blood rheology. This research will be test on an 8 week old, 300-330g Sprague–Dawley (SD) Rats for 20 days by give it Triiodothyronine through its mouth. After giving the Triiodothyronine, we will draw blood from the rats and test its blood viscosity, deformability of the red blood cell, and gather rate of red blood cell. From the report we will learn the hyperfunction of Triiodothyronine in the rat’s blood. From the current testing result we found that 20 days after using Triiodothyronine on rats, Triiodothyronine obviously increased in its blood serum, but we also found the decrease in its L-thyroine. However, the fibrinogen in the rat’s blood could be raise and Blood viscosity increases in low shear rate. Hyperthyroidism cause lipid peroxidation in RBC membrane and free radical increases in blood.