| Summary: | 碩士 === 國立陽明大學 === 生物醫學影像暨放射科學系暨研究所 === 96 === Statistical parametric mapping (SPM) is an approach to perform voxel-by-voxel statistical analysis on functional brain volume images. The default brain template in SPM is ICBM 152 template which was constructed by western brains. However, the hemispheric shape differences appear between eastern and western races. This study aims to construct a local template from the MRI T1 brain volume images of 77 Taiwanese normal subjects Taiwanese. To validate this Taiwanese template, we applied two single-session fMRI experiments (one visual and one motor studies), two voxel-based morphometry (VBM) experiments (gender-discrepancy and normal versus bipolar disorder), and one deformation-based morphometry (DBM) experiment (normal versus bipolar disorder) to compare the differences between Taiwanese template and default ICBM 152 template. Our findings showed that, in within-subject analyses as our fMRI experiment, template difference had insignificant influence on the SPM results. However, in multi-subjects analyses such as VBM experiments, the template-related difference has a main effect on the SPM results. Accordingly, in comparison with ICBM 152 template, it is suggested that Taiwanese template was a more appropriate template in the case of VBM gender-discrepancy experiment for Taiwanese subjects. Finally, in the DBM based experiment, it is indicated that image data would have less bias in the process of normalizing to Taiwanese template compared to ICBM 152 template. Based on our findings, the morphological differences of brain between races can result in the different outcome of SPM for multi-subjects and the case-driven template is recommended to obtain more precisely statistical results. Our Taiwanese template obtained from the sufficient amount of database can be used as a default template for other Taiwanese-related SPM studies.
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