Prospective study on the association of mannose-binding lectin Polymorphisms with Pap smear abnormality and persistently high-risk human papillomavirus infection

• Main Authors: Ching Chou Tsai, 蔡景州
• Other Authors: F.L. Eng
• Format: Others
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/67019082804536763409

碩士 === 長庚大學 === 臨床醫學研究所 === 97 === ABSTRACT OBJECTIVE: Mannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. Presently, we investigated the association of mbl-2 functional polymorphisms with human papillomavirus (HPV) infection, a primary etiological factor for cervical cancer. STUDY DESIGN: The frequencies of haplotypes and genotypes of mbl-2 exon1 and promoter region variants were analyzed in 150 HPV + patients and 277 HPV - controls. Unconditional logistic regression analysis was performed to evaluate an association between specific mbl-2 alleles and susceptibility to HPV infection. RESULTS: The frequency of high-producer mbl-2 genotypes (HY/HY) was higher in HPV + patients than in HPV - controls (p<0.001). The genotype of the mbl-2 gene polymorphisms HY/LX represented the least significant risk for the HPV + group. CONCLUSION: Certain polymorphisms in the MBL promoter region are increased among cervical samples demonstrating HPV infection. This finding suggests a potential link between MBL and high-risk HPV infection.